Projects and Patents

ORGAN REGENERATION METHOD UTILIZING iPS CELL AND BLASTOCYST COMPLEMENTATION

Application Field(s) Regenerative Medicine, Animal Engineering,
FEATURES In a blastocyst complementation method, it is found that the regeneration of an organ can be achieved by utilizing a fact that the defect in an organ such as pancreas can be complemented by injecting an induced pluripotent stem cell (an iPS cell) into a developed blastocyst.  Disclosed is a method, in a living body of a non-human mammal having such an abnormality that a desired organ cannot be developed in the development stage, for producing an organ that is the same as the desired organ and is derived from a mammal different from the non-human mammal by using an iPS cell.
INTELLECTUAL PROPERTY STATUS WO/2010/021390,  PCT/JP2009/064676, JP 2010-525712, US20110258715,
CN10296722, GB2475656 (issued), GB2490443 (issued),
Principal Inventor:  Prof. Hiromitsu Nakauchi

Regenerating Human iPS cell-derived Pancreas

METHOD FOR PRODUCING FOUNDER ANIMAL FOR REPRODUCING ANIMAL HAVING LETHAL PHENOTYPE CAUSED BY GENE MODIFICATION

Application Field(s) Regenerative Medicine, Animal Engineering,
FEATURES Disclose is a technique for constantly enabling organ regeneration in order to establish organ regeneration at improved efficiency. It is found out that, in the blastocyst complementation method, a next generation is born by injecting ES cells into the generated blastocysts to thereby complement a defect in an organ such as pancreas, kidney or the like. Further, it is found out that a transgenic animal in which the pancreas or kidney has been thus complemented can transmit the phenotype to the next generation as a founder. Thus, it is clarified that an organ can be regenerated by using such a founder.
INTELLECTUAL PROPERTY STATUS WO/2009/104794,  PCT/JP2009/053232 , JP 2009-554423, US20110067125,
EP2258166,
Principal Inventor: Prof. Hiromitsu Nakauchi

METHOD FOR PRODUCING XENOGENEIC EMBRYONIC CHIMERIC ANIMAL USING STEM CELL

Application Field(s) Regenerative Medicine, Animal Engineering,
FEATURES A xenogeneic chimeric animal can be produced by a method comprising the following steps (A) and (B): (A) injecting a stem cell into a blastocystic cavity in a blastocyst state of an animal heterogeneous to the stem cell, or mixing the stem cell with a fertilized ovum of an animal heterogeneous to the stem cell which has been divided, thereby producing a cell mass containing the stem cell; and (B) making the cell mass produced in step (A) grow into a chimeric animal of the species of an organism from which the stem cell is collected and the species of the animal heterogeneous to the stem cell.
INTELLECTUAL PROPERTY STATUS WO/2008/087459,  PCT/JP2010/051288, JP 2010-548574, US2011283374,
Principal Inventor:  Prof. Hiromitsu Nakauchi